Xue Han

Xue developed optical control neural technologies with the Synthetic Neurobiology group from the very beginning, working as a postdoctoral fellow in Bob Desimone’s lab. Beforehand, Xue did a Ph.D. at the University of Wisconsin, where she investigated the structure and dynamics of the initial structure formed between synaptic vesicles and the plasma membrane during calcium-trigged exocytosis, and she also did a brief postdoctoral fellowship at Stanford University where she studied how oculomotor events influence the primate visual system, as a Helen Hay Whitney Postdoctoral Fellow. Xue also recived a K99/R00 NIH Pathway to Independence Award. After finishing her work at MIT, Xue went on to start her own lab in 2010 at Boston University, as an assistant professor of bioengineering.

Publications

Multi-neuron intracellular recording in vivo via interacting autopatching robots

Elife | 2018

Kodandaramaiah SB, Flores FJ, Holst GL, Singer AC, Han X, Brown EN, Boyden ES*, Forest CR* (2018) Multi-neuron intracellular recording in vivo via interacting autopatching robots, Elife 7:e24656. (*, co-corresponding authors)

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

Nature Neuroscience | 2014

Chuong, A. S., Miri, M. L.*, Busskamp, V.*, Matthews, G.A.C.*, Acker, L.C.*, Soresnsen, A.T., Young, A., Klapoetke, N. C., Henninger, M.A., Kodandaramaiah, S.B., Ogawa, M., Ramanlal, S. B., Bandler, R. C., Allen, B. D., Forest, C.R., Chow, B.Y., Han, X., Lin, Y., Tye, K.M., Roska, B., Cardin, J.A., Boyden, E. S. (2014) Noninvasive optical inhibition with a red-shifted microbial rhodopsin, Nature Neuroscience 17:1123-1129. (*, equal contribution)

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

Nature Neuroscience | 2012

Madisen, L., Mao, T., Koch, H., Zhuo, J.-m., Berenyi, A., Fujisawa, S., Hsu, Y.-W., Garcia, A. J., Gu, X., Zanella, S., Kidney, J., Gu, H., Mao, Y., Hooks, B. M., Boyden, E. S., Buzsáki, G., Ramirez, J. M., Jones, A. R., Svoboda, K., Han, X., Turner, E. E., Zeng, H. (2012) A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing, Nature Neuroscience 15(5):793-802.

Genetically encoded molecular tools for light-driven silencing of targeted neurons

Progress in Brain Research | 2012

Chow B.Y., Han, X., Boyden, E. S. (2012) Genetically encoded molecular tools for light-driven silencing of targeted neurons, Progress in Brain Research 196:49-61.

Striatal origin of the pathologic beta oscillations in Parkinson's disease

Proceedings of the National Academy of Sciences | 2011

McCarthy, M. M., Moore-Kochlacs, C., Xuan Gu, T., Boyden, E. S., Han, X., Kopell, N. J. (2011) Striatal origin of the pathologic beta oscillations in Parkinson’s disease, Proceedings of the National Academy of Sciences 108(28):11620-5.

A high-light sensitivity optical neural silencer: development, and application to optogenetic control of nonhuman primate cortex

Frontiers in Systems Neuroscience | 2011

Han, X.*, Chow, B. Y.*, Zhou, H., Klapoetke, N. C., Chuong, A., Rajimehr, R., Yang, A., Baratta, M. V., Winkle, J., Desimone, R., Boyden, E. S. (2011) A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex, Frontiers in Systems Neuroscience 5:18. (* co-first authors)

Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons

Neuromethods | 2011

Chow, B. Y., Han, X., Bernstein, J. G., Monahan, P. E., Boyden, E. S. (2011) Light-Activated Ion Pumps and Channels for Temporally Precise Optical Control of Activity in Genetically Targeted Neurons, Chapter 6, Photosensitive Molecules for Controlling Biological Function, edited by James J. Chambers and Richard H. Kramer, Neuromethods Series Volume 55, Humana Press.

High-performance genetically targetable optical neural silencing by light-driven proton pumps

Nature | 2010

Chow, B. Y.*, Han, X.*, Dobry, A. S., Qian, X., Chuong, A. S., Li, M., Henninger, M. A., Belfort, G. M., Lin, Y., Monahan, P. E., Boyden, E. S. (2010) High-performance genetically targetable optical neural silencing by light- driven proton pumps, Nature 463:98-102. (* co-first authors)

New Techniques for Investigating Brain Rhythms: Optical Neural Control and Multielectrode Recording

Society for Neuroscience | 2009

Boyden, E. S., Han, X., Talei Franzesi, G., Chan, S., Bernstein, J., Qian, X., Li, M. (2009) "New Techniques for Investigating Brain Rhythms: Optical Neural Control and Multielectrode Recording," In: Rhythms of the Neocortex: Where Do They Come From and What Are They Good For? (Kopell N., ed.) pp. 65-75. Washington, DC: Society for Neuroscience.

Informational Lesions: Optical Perturbation of Spike Timing and Neural Synchrony Via Microbial Opsin Gene Fusions

Frontiers in Molecular Neuroscience | 2009

Han X., Qian X., Stern P., Chuong A. and Boyden E.S. (2009) Informational Lesions: Optical Perturbation of Spike Timing and Neural Synchrony Via Microbial Opsin Gene Fusions, Frontiers in Molecular Neuroscience 2:12.

Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain

Neuron | 2009

Han, X.*, Qian, X., Bernstein, J.G., Zhou, H.-H., Talei Franzesi, G., Stern, P., Bronson, R.T., Graybiel, A.M., Desimone, R., and Boyden, E.S.* (2009) Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain, Neuron 62(2):191-198. (* co-corresponding authors)

Prosthetic systems for therapeutic optical activation and silencing of genetically-targeted neurons

Proc Soc Photo Opt Instrum Eng | 2008

Bernstein, J. G., Han, X., Henninger, M. A., Ko, E. Y., Qian, X., Franzesi, G. T., McConnell, J. P., Stern, P., Desimone, R., and Boyden, E. S. (2008) Prosthetic systems for therapeutic optical activation and silencing of genetically-targeted neurons, Proc Soc Photo Opt Instrum Eng 6854:68540H.

Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution

PLoS ONE | 2007

Han, X. and Boyden, E. S. (2007) Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution, PLoS ONE 2(3): p. e299.