Resources

Tools for mapping the molecular structure of the brain

Expansion microscopy: physical magnification with nanoscale precision

Pumby: programmable, modular RNA binding proteins

Tools for recording high-speed brain dynamics

Archon1: well-localized, high-sensitivity, photostable fluorescent voltage indicator

Autopatching: robotic patch clamp in live brain

Fluorescent proteins evolved by rapid directed molecular evolution

KRaION: affinity-tuned genetically encoded fluorescent potassium indicator

Lightfield microscopy: fast 3-D neural imaging

SiRIs: spatial multiplexing of fluorescent reporters for imaging signaling network dynamics

SomaGCaMP: soma-targeted calcium indicators for precision neural population imaging

SomArchon: voltage indicator for population neural activity imaging

TMI: Temporally multiplexed imaging of signaling network dynamics

XRIs: expression recording islands for recording physiology into protein chains

Optogenetics: molecules enabling neural control by light

Accessory plasmids for optogenetics

Arch: archaerhodopsin (light-driven proton pump)

ArchT: light-sensitive archaerhodopsin

ChR2-2A-Halo: channelrhodopsin-halorhodopsin gene fusions

ChR2: channelrhodopsin-2 (light-driven cation channel)

Chrimson: red light-drivable channelrhodopsin

ChromeQ: optogenetic activation with reduced proton and calcium currents

Chronos: high-speed, light-sensitive, channelrhodopsin

CoChR: large-current channelrhodopsin

Glial optogenetic tools

Halo/NpHR: halorhodopsin (light-driven chloride pump)

Jaws: red light-drivable halorhodopsin

Lentivirus production for high-titer, cell-specific, in vivo neural labeling

Lumitoxins: light-actuated tethered toxin architecture

Mac: light-driven proton pump of L. maculans

soCoChR: soma-targeted, high-amplitude channelrhodopsin

Optogenetics: hardware enabling neural control by light

Versatile, but Manually-Assembled, Optical Fiber/Laser System for In Vivo Optogenetics

Very Simple Off-The-Shelf Systems for In Vivo Optogenetics

Understanding normal and pathological brain computations

Closed-loop, ultraprecise, automated craniotomies