Ho-Jun Suk
Ho-Jun Suk completed his Medical Engineering/Medical Physics Ph. D. in the Harvard/MIT Division of Health Sciences and Technology, working on robotic technologies for analyzing cells. He received the B.S. and M.S. degrees in Electrical and Computer Engineering from Cornell and University of Illinois at Urbana-Champaign respectively. Then as a postdoc, he worked on novel treatments for Alzheimer’s disease, working between the labs of Li-Huei Tsai and Ed Boyden. He then went on to a startup company in the biotech space.
Publications
Expansion Sequencing: Spatially Precise In Situ Transcriptomics in Intact Biological Systems
Science | 2021Alon S*, Goodwin DR*, Sinha A*, Wassie AT*, Chen F*, Daugharthy ER**, Bando Y, Kajita A, Xue AG, Marrett K, Prior R, Cui Y, Payne AC, Yao CC, Suk HJ, Wang R, Yu CJ, Tillberg P, Reginato P, Pak N, Liu S, Punthambaker S, Iyer EPR, Kohman RE, Miller JA, Lein ES, Lako A, Cullen N, Rodig S, Helvie K, Abravanel DL, Wagle N, Johnson BE, Klughammer J, Slyper M, Waldman J, Jané-Valbuena J, Rozenblatt-Rosen O, Regev A; IMAXT Consortium, Church GM***+, Marblestone AH***, Boyden ES***+ (2021) Expansion Sequencing: Spatially Precise In Situ Transcriptomics in Intact Biological Systems, Science 371(6528):eaax2656. (* equal contribution, ** key contributions to early stages of project, *** equal contribution, +co-corresponding authors)
Sparse decomposition light-field microscopy for high speed imaging of neuronal activity
Optica | 2020Young-Gyu Yoon*, Zeguan Wang*, Nikita Pak, Demian Park, Peilun Dai, Jeong Seuk Kang, Ho-Jun Suk, Panagiotis Symvoulidis, Burcu Guner-Ataman, Kai Wang**, and Edward S. Boyden** (2020) Sparse decomposition light-field microscopy for high speed imaging of neuronal activity, Optica 7(10):1457-1468. (* equal contributors, ** equal contributors)
Advances in the automation of whole-cell patch clamp technology
Journal of Neuroscience Methods | 2019Suk HJ, Boyden ES, van Welie I (2019) Advances in the automation of whole-cell patch clamp technology, Journal of Neuroscience Methods 326:108357.
Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection
Neuron | 2019Adaikkan C, Middleton SJ, Marco A, Pao PC, Mathys H, Kim DN, Gao F, Young JZ, Suk HJ, Boyden ES, McHugh TJ, Tsai LH (2019) Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection, Neuron 102(5):929-943.
Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition
Cell | 2019Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, Young JZ, Kim DN, Kritskiy O, Barker SJ, Mangena V, Prince SM, Brown EN, Chung K, Boyden ES, Singer AC, Tsai LH (2019) Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition, Cell 177(2):256-271.
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters
Nature Chemical Biology | 2018Piatkevich KD*, Jung EE*, Straub C, Linghu C, Park D, Suk HJ, Hochbaum DR, Goodwin D, Pnevmatikakis E, Pak N, Kawashima T, Yang CT, Rhoades JL, Shemesh O, Asano S, Yoon YG, Freifeld L, Saulnier JL, Riegler C, Engert F, Hughes T, Drobizhev M, Szabo B, Ahrens MB, Flavell SW, Sabatini BL, Boyden ES (2018) A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters, Nature Chemical Biology 14(4):352-360. (*, co-first authors)
Near-Infrared Fluorescent Proteins Engineered from Bacterial Phytochromes in Neuroimaging
Biophysical Journal | 2017Piatkevich KD, Suk HJ, Kodandaramaiah SB, Yoshida F, DeGennaro EM, Drobizhev M, Hughes TE, Desimone R, Boyden ES*, Verkhusha VV* (2017) Near-Infrared Fluorescent Proteins Engineered from Bacterial Phytochromes in Neuroimaging, Biophysical Journal 113(10):2299-2309. (*, co-corresponding authors)
Closed-Loop Real-Time Imaging Enables Fully Automated Cell-Targeted Patch-Clamp Neural Recording In Vivo
Neuron | 2017Ho-Jun Suk, Ingrid van Welie, Suhasa B. Kodandaramaiah, Brian Allen, Craig R. Forest, Edward S. Boyden (2017) Closed-Loop Real-Time Imaging Enables Fully Automated Cell-Targeted Patch-Clamp Neural Recording In Vivo, Neuron 95(5):1037-1047.
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields
Cell | 2017Grossman N, Bono D, Dedic N*, Kodandaramaiah SB*, Rudenko A, Suk HJ, Cassara AM, Neufeld E, Kuster N, Tsai LH, Pascual-Leone A, Boyden ES (2017) Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, Cell 169(6):1029-1041. (* equal contribution)
Iterative expansion microscopy
Nature Methods | 2017Chang, J.-B., Chen, F., Yoon, Y.-G., Jung, E. E., Babcock H., Kang J.-S., Asano S., Suk H.-J., Pak N., Tillberg P.W., Wassie A., Cai D., Boyden E.S. (2017) Iterative expansion microscopy, Nature Methods 14:593-599.
Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies
Nature Biotechnology | 2016Tillberg, P.W.*, Chen, F.*, Piatkevich, K.D., Zhao, Y., Yu, C.-C., English, B.P., Gao, L., Martorell, A., Suk, H.-J., Yoshida, F., DeGennaro, E.M., Roossien, D.H., Gong, G., Seneviratne, U., Tannenbaum, S.R., Desimone, R., Cai, D., Boyden, E.S. (2016) Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies, Nature Biotechnology 34:987-992. (*, co-first authors)