Chi Zhang

Email: chiz, followed by @MIT.EDU

Chi completed his BS in Chemistry from Peking University in China in 2012. After obtaining his Ph.D. in Chemical Biology in the Pentelute lab at MIT Chemistry Department, he joined the Boyden lab in 2017 as a postdoctoral fellow (co-mentored with Prof. Pentelute). Chi is interested in developing new chemistry approaches to precisely and accurately profile complex biological systems.

Publications

Expansion microscopy using a single anchor molecule for high-yield multiplexed imaging of proteins and RNAs

PLoS One | 2023

Cui Y*, Yang G*, Goodwin DR, O'Flanagan CH, Sinha A, Zhang C, Kitko KE, Shin TW, Park D, Aparicio S; CRUK IMAXT Grand Challenge Consortium; Boyden ES (2023) Expansion microscopy using a single anchor molecule for high-yield multiplexed imaging of proteins and RNAs, PLoS One 18(9):e0291506. (*, contributed equally)

Photo-expansion microscopy enables super-resolution imaging of cells embedded in 3D hydrogels

Nature Materials | 2023

Günay KA, Chang TL, Skillin NP, Rao VV, Macdougall LJ, Cutler AA, Silver JS, Brown TE, Zhang C, Yu CJ, Olwin BB, Boyden ES, Anseth KS (2023) Photo-expansion microscopy enables super-resolution imaging of cells embedded in 3D hydrogels, Nature Materials 22(6):777-785.

Recording of cellular physiological histories along optically readable self-assembling protein chains

Nature Biotechnology | 2023

Linghu C, An B, Shpokayte M, Celiker OT, Shmoel N, Zhang R, Zhang C, Park D, Park WM, Ramirez S, Boyden ES (2023) Recording of cellular physiological histories along optically readable self-assembling protein chains, Nature Biotechnology 41(5):640-651.

Expansion Microscopy for Beginners: Visualizing Microtubules in Expanded Cultured HeLa Cells

Current Protocols in Neuroscience | 2020

Zhang C*, Kang JS*, Asano SM, Gao R, Boyden ES (2020) Expansion Microscopy for Beginners: Visualizing Microtubules in Expanded Cultured HeLa Cells, Current Protocols in Neuroscience 92(1):e96. (*, contributed equally)

Expansion microscopy of C. elegans

eLife | 2020

Yu CJ, Barry NC, Wassie AT, Sinha A, Bhattacharya A, Asano S, Zhang C, Chen F, Hobert O, Goodman MB, Haspel G, Boyden ES (2020) Expansion microscopy of C. elegans, eLife 9:e46249.