Tay Shin

Tay Shin, while a graduate student in the Synthetic Neurobiology Group at MIT, developed new methods for visualizing brain circuitry through lipid staining and expansion microscopy imaging. While at UC Berkeley, he pursued various statistical modeling research projects, and after graduation, he spent two years working as a data scientist for South Korean government agencies, where he created an econometrics machine learning model that eventually saved the South Korean government 200 million dollars.

Publications

Single-shot 20-fold expansion microscopy

Nature Methods | 2024

Wang S*, Shin TW*, Yoder HB 2nd, McMillan RB, Su H, Liu Y, Zhang C, Leung KS, Yin P, Kiessling LL**, Boyden ES** (2024) Single-shot 20-fold expansion microscopy, Nature Methods, doi:10.1038/s41592-024-02454-9. Online ahead of print. (*, equal contribution; **, co-corresponding authors)

Dense, Continuous Membrane Labeling and Expansion Microscopy Visualization of Ultrastructure in Tissues

bioRxiv | 2024

Tay Won Shin, Hao Wang*, Chi Zhang*, Bobae An, Yangning Lu, Elizabeth Zhang, Xiaotang Lu, Emmanouil D Karagiannis, Jeong Seuk Kang, Amauche Emenari, Panagiotis Symvoulidis, Shoh Asano, Leanne Lin, Emma K Costa; IMAXT Grand Challenge Consortium; Adam H Marblestone, Narayanan Kasthuri, Li-Huei Tsai, Edward S Boyden (2024) Dense, Continuous Membrane Labeling and Expansion Microscopy Visualization of Ultrastructure in Tissues, bioRxiv 2024.03.07.583776; doi: https://doi.org/10.1101/2024.03.07.583776 (*, equal contribution)

A marmoset brain cell census reveals regional specialization of cellular identities

Science Advances | 2023

Krienen FM, Levandowski KM, Zaniewski H, Del Rosario RCH, Schroeder ME, Goldman M, Wienisch M, Lutservitz A, Beja-Glasser VF, Chen C, Zhang Q, Chan KY, Li KX, Sharma J, McCormack D, Shin TW, Harrahill A, Nyase E, Mudhar G, Mauermann A, Wysoker A, Nemesh J, Kashin S, Vergara J, Chelini G, Dimidschstein J, Berretta S, Deverman BE, Boyden E, McCarroll SA, Feng G (2023) A marmoset brain cell census reveals regional specialization of cellular identities, Science Advances 9(41):eadk3986.

Expansion microscopy using a single anchor molecule for high-yield multiplexed imaging of proteins and RNAs

PLoS One | 2023

Cui Y*, Yang G*, Goodwin DR, O'Flanagan CH, Sinha A, Zhang C, Kitko KE, Shin TW, Park D, Aparicio S; CRUK IMAXT Grand Challenge Consortium; Boyden ES (2023) Expansion microscopy using a single anchor molecule for high-yield multiplexed imaging of proteins and RNAs, PLoS One 18(9):e0291506. (*, contributed equally)

Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation

ACS Nano | 2023

Al Mahbuba D, Masuko S, Wang S, Syangtan D, Kang JS, Song Y, Shin TW, Xia K, Zhang F, Linhardt RJ, Boyden ES, Kiessling LL (2023) Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation, ACS Nano 17(8):7207-7218.

Expansion Microscopy of Lipid Membranes

bioRxiv | 2019

Emmanouil D. Karagiannis*, Jeong Seuk Kang*, Tay Won Shin, Amauche Emenari, Shoh Asano, Leanne Lin, Emma K. Costa, IMAXT Grand Challenge Consortium, Adam H. Marblestone, Narayanan Kasthuri, Edward S. Boyden (2019) Expansion Microscopy of Lipid Membranes, bioRxiv 829903. (*, equal contribution)