Orhan Celiker

Orhan completed a PhD in the department of Electrical Engineering and Computer Science at MIT. He received his B.Sc. in Electrical Engineering at Bilkent University, Ankara, Turkey, followed by his SM degree at MIT on the Quantum Electron Microscope project. His PhD helped enable many new molecular tools for precise imaging of neural activity, and helped empower new approaches for analysis of C. elegans neural dynamics.

Publications

Recording of cellular physiological histories along optically readable self-assembling protein chains

Nature Biotechnology | 2023

Linghu C, An B, Shpokayte M, Celiker OT, Shmoel N, Zhang R, Zhang C, Park D, Park WM, Ramirez S, Boyden ES (2023) Recording of cellular physiological histories along optically readable self-assembling protein chains, Nature Biotechnology 41(5):640-651.

Temporally multiplexed imaging of dynamic signaling networks in living cells

bioRxiv | 2022

Yong Qian, Orhan T. Celiker, Zeguan Wang, Burcu Guner-Ataman, Edward S. Boyden (2022) Temporally multiplexed imaging of dynamic signaling networks in living cells, bioRxiv 2022.08.22.504781; doi: https://doi.org/10.1101/2022.08.22.504781.

Improved genetically encoded near-infrared fluorescent calcium ion indicators for in vivo imaging

PLoS Biology | 2020

Qian Y, Cosio DMO, Piatkevich KD, Aufmkolk S, Su WC, Celiker OT, Schohl A, Murdock MH, Aggarwal A, Chang YF, Wiseman PW, Ruthazer ES, Boyden ES, Campbell RE (2020) Improved genetically encoded near-infrared fluorescent calcium ion indicators for in vivo imaging, PLoS Biology 18(11):e3000965.

Spatial multiplexing of fluorescent reporters for imaging signaling network dynamics

Cell | 2020

Changyang Linghu*, Shannon L. Johnson*, Pablo A. Valdes, Or A. Shemesh, Won Min Park, Demian Park, Kiryl D. Piatkevich, Asmamaw T. Wassie, Yixi Liu, Bobae An, Stephanie A. Barnes, Orhan T. Celiker, Chun-Chen Yao, Chih-Chieh (Jay) Yu, Ru Wang, Katarzyna P. Adamala, Mark F. Bear, Amy E. Keating and Edward S. Boyden (2020) Spatial multiplexing of fluorescent reporters for imaging signaling network dynamics, Cell 183(6):1682-1698. (*, equal contribution)

Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator

Neuron | 2020

Shemesh OA*, Linghu C*, Piatkevich KD*, Goodwin D, Celiker OT, Gritton HJ, Romano MF, Gao R, Yu CJ, Tseng HA, Bensussen S, Narayan S, Yang CT, Freifeld L, Siciliano CA, Gupta I, Wang J, Pak N, Yoon YG, Ullmann JFP, Guner-Ataman B, Noamany H, Sheinkopf ZR, Park WM, Asano S, Keating AE, Trimmer JS, Reimer J, Tolias AS, Bear MF, Tye KM, Han X, Ahrens MB, Boyden ES (2020) Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator, Neuron 107(3):470-486. (*, equal contribution)

Expansion Microscopy of Zebrafish for Neuroscience and Developmental Biology Studies

Proceedings of the National Academy of Sciences | 2017

Freifeld L, Odstrcil I, Förster D, Ramirez A, Gagnon JA, Randlett O, Costa EK, Asano S, Celiker OT, Gao R, Martin-Alarcon DA, Reginato P, Dick C, Chen L, Schoppik D, Engert F, Baier H, Boyden ES (2017) Expansion microscopy of zebrafish for neuroscience and developmental biology studies, Proceedings of the National Academy of Sciences 114(50):E10799-E10808.