ChromeQ: optogenetic activation with reduced proton and calcium currents

Publication [Cho YK, Park D*, Yang A*, Chen F, Chuong AS, Klapoetke NC, Boyden ES (2019) Multidimensional screening yields channelrhodopsin variants having improved photocurrent and order-of-magnitude reductions in calcium and proton currents, Journal of Biological Chemistry 294(11):3806-3821. (*, equal contribution)]

Plasmids, plasmid maps, and plasmid preparation protocols, as well as viruses (AAV, lentivirus), available at [Addgene]

Viruses (AAV, lentivirus) available at [UNC vector core]

Viruses (AAV, lentivirus) available at [U. Penn vector core]

Project

Optogenetics: molecules enabling neural control by light

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Publications