In this work, we report progress in developing
a device that allows fully autonomous sequential patch
clamp experimentation. The
machine works by integrating a storage
magazine of pre-filled pipettes that can be
accessed, and swapped, by the headstage at
the conclusion of each experiment. In operation,
following each neuron measurement, the
program enters “swap” state where a set of
programmed actuator movements take place.
First, the headstage translates towards the
pipette storage assembly and deposits its used
pipette. The storage assembly rotates to index a
fresh pipette, its is grasped, and finally, the
headstage returns to its previously designated
home position in preparation of subsequent
experiments.
