“Time after time we have rushed back to nature’s cupboard for cures to illnesses,” noted the United Nations in declaring 2010 the International Year of Biodiversity. Billions of years of evolution have equipped natural organisms with an incredible diversity of genetically encoded wealth, which, given our biological nature as humans, presents great potential when it comes to understanding our physiology and advancing our medicine. Natural products such as penicillin and aspirin are used daily to treat disease, yeast and corn yield biofuels, and viruses can deliver therapeutic genes into the body. Some of the most powerful tools for understanding biology, such as the PCR reaction, which enables DNA to be amplified and analyzed starting from tiny samples, or the green fluorescent protein (GFP), which glows green and thus enables proteins and processes to be visualized in living cells, are bioengineering applications of genes that occur in specialized organisms in specific ecological niches. But how exactly do these tools make it from the wild to benchtop or bedside?