Paul Reginato

Paul, while in the group, worked on technology that integrates the high-dimensional ‘omic’ data that characterizes modern biology, with the 3-dimensional reality of biological systems. The big picture goal, in collaboration with many others, of his thesis work was to know the function and location of biomolecules of interest throughout tissues — that is, obtaining comprehensive molecular maps of tissues. To approach this goal, he applied and extended fluorescent in situ sequencing (FISSEQ) and expansion microscopy (ExM) technologies, towards the 3-d analysis of the structure of the genome. Paul completed a BS degree in Biology and Mathematics from the University of Waterloo. As a Biological Engineering PhD student at the Massachusetts Institute of Technology, Paul worked in the Boyden lab and the Church lab (Harvard) on novel biotechnologies.