Panos Symvoulidis

Email: symvou, followed by @mit.edu

Panos is a postdoctoral associate in the Synthetic Neurobiology group at MIT. He acquired his Electrical and Computer Engineering Diploma from the NTUA (Greece). During his Ph.D. at the TU Munich (Germany), he worked on (pre-)clinical cancer imaging using optical methods. Later on, Panos focused on the transparent brains of zebrafish larvae and he engineered a novel tracking microscope. Intrigued by the neural circuits that give rise to behaviour, he joined the Synthetic Neurobiology group to expand and use novel tools to understand the structure and function of the larval zebrafish brain.

Publications

Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues

Nature Communications | 2025

Shin TW, Wang H*, Zhang C*, An B, Lu Y, Zhang E, Lu X, Karagiannis ED, Kang JS, Emenari A, Symvoulidis P, Asano S, Lin L, Costa EK; IMAXT Grand Challenge Consortium; Marblestone AH, Kasthuri N, Tsai LH, Boyden ES (2025) Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues, Nature Communications 16(1):1579. (*, contributed equally)

Fast light-field 3D microscopy with out-of-distribution detection and adaptation through conditional normalizing flows

Biomedical Optics Express | 2024

Page Vizcaíno J, Symvoulidis P, Wang Z, Jelten J, Favaro P, Boyden ES, Lasser T (2024) Fast light-field 3D microscopy with out-of-distribution detection and adaptation through conditional normalizing flows, Biomedical Optics Express 15(2):1219-1232.

Imaging the voltage of neurons distributed across entire brains of larval zebrafish

bioRxiv | 2023

Zeguan Wang*, Jie Zhang*, Panagiotis Symvoulidis, Wei Guo, Lige Zhang, Matthew A. Wilson, Edward S. Boyden (2023) Imaging the voltage of neurons distributed across entire brains of larval zebrafish bioRxiv 2023.12.15.571964; doi: https://doi.org/10.1101/2023.12.15.571964 (*, co-first authors)

Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity

Human Molecular Genetics | 2023

Pigoni M, Uzquiano A, Paulsen B, Kedaigle AJ, Yang SM, Symvoulidis P, Adiconis X, Velasco S, Sartore R, Kim K, Tucewicz A, Tropp SY, Tsafou K, Jin X, Barrett L, Chen F, Boyden ES, Regev A, Levin JZ, Arlotta P (2023) Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity, Human Molecular Genetics 32(18):2773-2786.

Autism genes converge on asynchronous development of shared neuron classes

Nature | 2022

Paulsen B, Velasco S, Kedaigle AJ, Pigoni M, Quadrato G, Deo AJ, Adiconis X, Uzquiano A, Sartore R, Yang SM, Simmons SK, Symvoulidis P, Kim K, Tsafou K, Podury A, Abbate C, Tucewicz A, Smith SN, Albanese A, Barrett L, Sanjana NE, Shi X, Chung K, Lage K, Boyden ES, Regev A, Levin JZ, Arlotta P (2022) Autism genes converge on asynchronous development of shared neuron classes, Nature 602(7896):268-273.

Real-Time Light Field 3D Microscopy via Sparsity-Driven Learned Deconvolution

2021 IEEE International Conference on Computational Photography (ICCP) | 2021

Vizcaino, Josue Page, Zeguan Wang, Panagiotis Symvoulidis, Paolo Favaro, Burcu Guner-Ataman, Edward S. Boyden, and Tobias Lasser (2021) Real-time light field 3D microscopy via sparsity-driven learned deconvolution, IEEE International Conference on Computational Photography (ICCP) 1-11.

Sparse decomposition light-field microscopy for high speed imaging of neuronal activity

Optica | 2020

Young-Gyu Yoon*, Zeguan Wang*, Nikita Pak, Demian Park, Peilun Dai, Jeong Seuk Kang, Ho-Jun Suk, Panagiotis Symvoulidis, Burcu Guner-Ataman, Kai Wang**, and Edward S. Boyden** (2020) Sparse decomposition light-field microscopy for high speed imaging of neuronal activity, Optica 7(10):1457-1468. (* equal contributors, ** equal contributors)