Kiryl Piatkevich
Kiryl received an MSc in Chemistry from M.V. Lomonosov Moscow State University, Russia. He then joined the Department of Anatomy and Structural Biology at Albert Einstein College of Medicine to work on the development of novel fluorescent proteins for advanced imaging techniques. Following the completion of his PhD Kiryl did a two year postdoctoral fellowship at Albert Einstein College of Medicine, where he developed near-infrared fluorescent probes for in vivo imaging. In the Synthetic Neurobiology group, he worked on novel methods of neural interfacing using synthetic biology. He then went on to a tenure-track faculty job at Westlake University.
Publications
Theta and gamma rhythmic coding through two spike output modes in the hippocampus during spatial navigation
Cell Reports | 2023Lowet E, Sheehan DJ, Chialva U, De Oliveira Pena R, Mount RA, Xiao S, Zhou SL, Tseng HA, Gritton H, Shroff S, Kondabolu K, Cheung C, Wang Y, Piatkevich KD, Boyden ES, Mertz J, Hasselmo ME, Rotstein HG, Han X (2023) Theta and gamma rhythmic coding through two spike output modes in the hippocampus during spatial navigation, Cell Reports 42(8):112906.
Large-scale voltage imaging in behaving mice using targeted illumination
iScience | 2021Xiao S, Lowet E, Gritton HJ, Fabris P, Wang Y, Sherman J, Mount RA, Tseng HA, Man HY, Straub C, Piatkevich KD, Boyden ES, Mertz J, Han X (2021) Large-scale voltage imaging in behaving mice using targeted illumination, iScience 24(11):103263.
A highly homogeneous polymer composed of tetrahedron-like monomers for high-isotropy expansion microscopy
Nature Nanotechnology | 2021Gao R*, Yu CJ*, Gao L, Piatkevich KD, Neve RL, Munro JB, Upadhyayula S, Boyden ES (2021) A highly homogeneous polymer composed of tetrahedron-like monomers for high-isotropy expansion microscopy, Nature Nanotechnology 16:698–707. (*, equal contribution)
Improved genetically encoded near-infrared fluorescent calcium ion indicators for in vivo imaging
PLoS Biology | 2020Qian Y, Cosio DMO, Piatkevich KD, Aufmkolk S, Su WC, Celiker OT, Schohl A, Murdock MH, Aggarwal A, Chang YF, Wiseman PW, Ruthazer ES, Boyden ES, Campbell RE (2020) Improved genetically encoded near-infrared fluorescent calcium ion indicators for in vivo imaging, PLoS Biology 18(11):e3000965.
Spatial multiplexing of fluorescent reporters for imaging signaling network dynamics
Cell | 2020Changyang Linghu*, Shannon L. Johnson*, Pablo A. Valdes, Or A. Shemesh, Won Min Park, Demian Park, Kiryl D. Piatkevich, Asmamaw T. Wassie, Yixi Liu, Bobae An, Stephanie A. Barnes, Orhan T. Celiker, Chun-Chen Yao, Chih-Chieh (Jay) Yu, Ru Wang, Katarzyna P. Adamala, Mark F. Bear, Amy E. Keating and Edward S. Boyden (2020) Spatial multiplexing of fluorescent reporters for imaging signaling network dynamics, Cell 183(6):1682-1698. (*, equal contribution)
Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator
Neuron | 2020Shemesh OA*, Linghu C*, Piatkevich KD*, Goodwin D, Celiker OT, Gritton HJ, Romano MF, Gao R, Yu CJ, Tseng HA, Bensussen S, Narayan S, Yang CT, Freifeld L, Siciliano CA, Gupta I, Wang J, Pak N, Yoon YG, Ullmann JFP, Guner-Ataman B, Noamany H, Sheinkopf ZR, Park WM, Asano S, Keating AE, Trimmer JS, Reimer J, Tolias AS, Bear MF, Tye KM, Han X, Ahrens MB, Boyden ES (2020) Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator, Neuron 107(3):470-486. (*, equal contribution)
Novel Genetically Encoded Bright Positive Calcium Indicator NCaMP7 Based on the mNeonGreen Fluorescent Protein
International Journal of Molecular Sciences | 2020Subach OM, Sotskov VP, Plusnin VV, Gruzdeva AM, Barykina NV, Ivashkina OI, Anokhin KV, Nikolaeva AY, Korzhenevskiy DA, Vlaskina AV, Lazarenko VA, Boyko KM, Rakitina TV, Varizhuk AM, Pozmogova GE, Podgorny OV, Piatkevich KD, Boyden ES, Subach FV (2020) Novel Genetically Encoded Bright Positive Calcium Indicator NCaMP7 Based on the mNeonGreen Fluorescent Protein, International Journal of Molecular Sciences 21(5):1644.
All-Optical Electrophysiology Reveals the Role of Lateral Inhibition in Sensory Processing in Cortical Layer 1
Cell | 2020Fan LZ, Kheifets S, Böhm UL, Wu H, Piatkevich KD, Xie ME, Parot V, Ha Y, Evans KE, Boyden ES, Takesian AE, Cohen AE (2020) All-Optical Electrophysiology Reveals the Role of Lateral Inhibition in Sensory Processing in Cortical Layer 1, Cell 180(3):521-535.
Population imaging of neural activity in awake behaving mice
Nature | 2019Piatkevich KD*, Bensussen S*, Tseng HA*, Shroff SN, Lopez-Huerta VG, Park D, Jung EE, Shemesh OA, Straub C, Gritton HJ, Romano MF, Costa E, Sabatini BL, Fu Z, Boyden ES**, Han X** (2019) Population imaging of neural activity in awake behaving mice, Nature 574:413–417. (* equal contribution, **, co-corresponding)
A genetically encoded near-infrared fluorescent calcium ion indicator
Nature Methods | 2019Qian Y, Piatkevich KD, Mc Larney B, Abdelfattah AS, Mehta S, Murdock MH, Gottschalk S, Molina RS, Zhang W, Chen Y, Wu J, Drobizhev M, Hughes TE, Zhang J, Schreiter ER, Shoham S, Razansky D, Boyden ES, Campbell RE (2018) A genetically encoded near-infrared fluorescent calcium ion indicator, Nature Methods 16(2):171-174.
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters
Nature Chemical Biology | 2018Piatkevich KD*, Jung EE*, Straub C, Linghu C, Park D, Suk HJ, Hochbaum DR, Goodwin D, Pnevmatikakis E, Pak N, Kawashima T, Yang CT, Rhoades JL, Shemesh O, Asano S, Yoon YG, Freifeld L, Saulnier JL, Riegler C, Engert F, Hughes T, Drobizhev M, Szabo B, Ahrens MB, Flavell SW, Sabatini BL, Boyden ES (2018) A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters, Nature Chemical Biology 14(4):352-360. (*, co-first authors)
Near-Infrared Fluorescent Proteins Engineered from Bacterial Phytochromes in Neuroimaging
Biophysical Journal | 2017Piatkevich KD, Suk HJ, Kodandaramaiah SB, Yoshida F, DeGennaro EM, Drobizhev M, Hughes TE, Desimone R, Boyden ES*, Verkhusha VV* (2017) Near-Infrared Fluorescent Proteins Engineered from Bacterial Phytochromes in Neuroimaging, Biophysical Journal 113(10):2299-2309. (*, co-corresponding authors)
Temporally precise single-cell resolution optogenetics
Nature Neuroscience | 2017Or A. Shemesh*, Dimitrii Tanese*, Valeria Zampini*, Changyang Linghu, Kiryl Piatkevich, Emiliano Ronzitti, Eirini Papagiakoumou, Edward S. Boyden+ and Valentina Emiliani+ (2017) Temporally precise single-cell resolution optogenetics, Nature Neuroscience 20:1796–1806. (*, co-first authors; +, co-corresponding authors)
Green fluorescent genetically encoded calcium indicator based on calmodulin/M13-peptide from fungi
PLoS One | 2017Barykina NV, Subach OM, Piatkevich KD, Jung EE, Malyshev AY, Smirnov IV, Bogorodskiy AO, Borshchevskiy VI, Varizhuk AM, Pozmogova GE, Boyden ES, Anokhin KV, Enikolopov GN, Subach FV (2017) Green fluorescent genetically encoded calcium indicator based on calmodulin/M13-peptide from fungi, PLoS One 12(8):e0183757.
Wide-field three-photon excitation in biological samples
Light: Science & Applications | 2017Rowlands, C.J., Park, D., Bruns, O.T., Piatkevich, K.D., Fukumura, D., Jain, R.K., Bawendi, M.G., Boyden, E.S. and So, P.T. (2017) Wide-field three-photon excitation in biological samples, Light: Science & Applications 6(5):e16255.
Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies
Nature Biotechnology | 2016Tillberg, P.W.*, Chen, F.*, Piatkevich, K.D., Zhao, Y., Yu, C.-C., English, B.P., Gao, L., Martorell, A., Suk, H.-J., Yoshida, F., DeGennaro, E.M., Roossien, D.H., Gong, G., Seneviratne, U., Tannenbaum, S.R., Desimone, R., Cai, D., Boyden, E.S. (2016) Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies, Nature Biotechnology 34:987-992. (*, co-first authors)