Bobae An

Email: bobaean, followed by @mit.edu

Bobae completed her Ph.D. in Neuroscience at Seoul National University. Her doctoral researches focused on cellular and molecular mechanisms of traumatic memory and its treatment. She then joined the Nicolelis Laboratory at Duke University as a postdoctoral associate and worked on characterization of brain-wide neural activity in neuropsychiatric disorders, with the goal of developing new diagnostic and treatment tools. She is currently a senior postdoctoral associate in the Synthetic Neurobiology group at MIT, where she researches novel methods for mapping brain circuits and how to apply such tools to understand brain function and disease.

Publications

Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context

bioRxiv | 2025

Park SY*, Sheridan A*, An B, Jarvis E, Lyudchik J, Patton W, Axup JY, Chan SW, Damstra HGJ, Leible D, Leung KS, Magno CA, Meeran A, Michalska JM, Rieger F, Wang C, Wu M, Church GM, Funke J, Huffman T, Leeper KGC**, Truckenbrodt S**, Winnubst J**, Kornfeld JMR, Boyden ES+, Rodriques SG***, Payne AC+*** (2025) Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context, bioRxiv 2025.09.26.678648, doi: 10.1101/2025.09.26.678648. (*, contributed equally; **, contributed equally; ***, contributed equally; +, co-corresponding)

Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues

Nature Communications | 2025

Shin TW, Wang H*, Zhang C*, An B, Lu Y, Zhang E, Lu X, Karagiannis ED, Kang JS, Emenari A, Symvoulidis P, Asano S, Lin L, Costa EK; IMAXT Grand Challenge Consortium; Marblestone AH, Kasthuri N, Tsai LH, Boyden ES (2025) Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues, Nature Communications 16(1):1579. (*, contributed equally)

Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding

Science Translational Medicine | 2024

Valdes PA, Yu CJ*, Aronson J*, Ghosh D, Zhao Y, An B, Bernstock JD, Bhere D, Felicella MM, Viapiano MS, Shah K, Chiocca EA**, Boyden ES** (2024) Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding, Science Translational Medicine 16(732):eabo0049. (*, contributed equally; **, contributed equally)

Recording of cellular physiological histories along optically readable self-assembling protein chains

Nature Biotechnology | 2023

Linghu C, An B, Shpokayte M, Celiker OT, Shmoel N, Zhang R, Zhang C, Park D, Park WM, Ramirez S, Boyden ES (2023) Recording of cellular physiological histories along optically readable self-assembling protein chains, Nature Biotechnology 41(5):640-651.

Spatial multiplexing of fluorescent reporters for imaging signaling network dynamics

Cell | 2020

Changyang Linghu*, Shannon L. Johnson*, Pablo A. Valdes, Or A. Shemesh, Won Min Park, Demian Park, Kiryl D. Piatkevich, Asmamaw T. Wassie, Yixi Liu, Bobae An, Stephanie A. Barnes, Orhan T. Celiker, Chun-Chen Yao, Chih-Chieh (Jay) Yu, Ru Wang, Katarzyna P. Adamala, Mark F. Bear, Amy E. Keating and Edward S. Boyden (2020) Spatial multiplexing of fluorescent reporters for imaging signaling network dynamics, Cell 183(6):1682-1698. (*, equal contribution)