Annabelle Singer

Annabelle, as a postdoc in the lab, investigated synaptic and ionic mechanisms in hippocampal neurons and circuits underlying learning and memory in awake behaving mice. To do this, Annabelle and collaborators developed awake autopatching, a new method for performing automated whole cell patch clamp of neurons in awake behaving animals. Additionally, Annabelle investigated how we remember important experiences, using optogenetic tools to manipulate circuitry involved in emotional processing to determine how these circuits alter memory. Annabelle received her Ph.D. from UCSF, performing research in the laboratory of Loren Frank, studying how reward modulates hippocampal memory processes and how this hippocampal activity predicts behavioral performance. She then moved on to a tenure-track faculty job at Georgia Tech.

Publications

Mesoscale-duration activated states gate spiking in response to fast rises in membrane voltage in the awake brain

Journal of Neurophysiology | 2017

Annabelle C. Singer*, Giovanni Talei Franzesi*, Suhasa B. Kodandaramaiah, Francisco J. Flores, Jeremy D. Cohen, Albert K. Lee, Christoph Borgers, Craig R. Forest, Nancy J. Kopell, Edward S. Boyden (2017) Mesoscale-duration activated states gate spiking in response to fast rises in membrane voltage in the awake brain, Journal of Neurophysiology 118(2):1270-1291.

Gamma frequency entrainment attenuates amyloid load and modifies microglia

Nature | 2016

Iaccarino HF*, Singer AC*, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH (2016) Gamma frequency entrainment attenuates amyloid load and modifies microglia, Nature 540(7632):230-235. (*, co-first authors)